Dynamiker Biotechnology(Tianjin) Co., Ltd.

Dynamiker Candida albicans IgG Assay is based on indirect Enzyme-linked Immunosorbent Assay (ELISA). It is used for the quantitative detection of Candida albicans anti-mannan IgG antibodies in human serum or plasma, offering a diagnostic reference for Candida albicans infection. The kit is intended for professional use only.

Candida albicans is an opportunistic pathogen that inhabits the skin, mouth, gastrointestinal tract and vagina. It is the most commonly-isolated yeast in invasive candidiasis (IC) and occupies more than 65% of IC ^[1]. Candida albicans can adhere to host tissues, produce secretory aspartyl proteases and phospholipase enzymes, and transform from yeast to hyphal phase, which is the major determinant of its pathogenicity. Risk factors for infections with Candida albicans include immunosuppression prior to steroid use, leukocytosis, intensive care unit stays, or presence of intravascular or urinary catheters.

Candida species are the fourth most common cause of all nosocomial bloodstream infections (BSIs). Nearly 50% of mortality is attributable to such infections ^[2]. Appropriate initial antimicrobial therapy plays critical role in IC management and delay in the initiation of therapy would significantly increase the mortality of IC. The presence of IgG antibodies against Candida albicans indicates prior Candida albicans infection and suggests immunity. A significant rise of IgG levels indicates an acute infection or a re-infection.